A good interview. A couple of other interesting points for reference:
@ about 34:00, Malone discusses the fundamental flaw in the logic of gene therapy. In the 1970s, people hoped to treat genetic disease in children by giving them the "good" gene to correct genetic defects, but people completely missed the problem of the immune response. Studies in mice showed that mice mount an immune response to the "good" gene expression, shutting it down in a couple of weeks. As it turns out, the only place gene therapy is working is in privileged compartments like the eye that don't have much of an immune response. Otherwise, you have to give immunosuppressants just like with transplants.
@ about 1:02:00, Malone discusses what is driving faster evolution of coronavirus mutations. Is it a pandemic of the unvaccinated? Are the unvaccinated putting the world at risk? No, it's a pandemic of the immunosuppressed and highly inoculated, who suffer chronic infection. He describes how they can watch the evolution of coronavirus in real time in a patient, as they were able to do with AIDS patients.
Ditto what Amanda said!
A good interview. A couple of other interesting points for reference:
@ about 34:00, Malone discusses the fundamental flaw in the logic of gene therapy. In the 1970s, people hoped to treat genetic disease in children by giving them the "good" gene to correct genetic defects, but people completely missed the problem of the immune response. Studies in mice showed that mice mount an immune response to the "good" gene expression, shutting it down in a couple of weeks. As it turns out, the only place gene therapy is working is in privileged compartments like the eye that don't have much of an immune response. Otherwise, you have to give immunosuppressants just like with transplants.
@ about 1:02:00, Malone discusses what is driving faster evolution of coronavirus mutations. Is it a pandemic of the unvaccinated? Are the unvaccinated putting the world at risk? No, it's a pandemic of the immunosuppressed and highly inoculated, who suffer chronic infection. He describes how they can watch the evolution of coronavirus in real time in a patient, as they were able to do with AIDS patients.
Thanks for taking the time to transcribe this. Your efforts in bringing so much information to us in a reader friendly format do not go unnoticed :)
Thanks. Hadda clean up the grammar.