Covid News And News
Multiple F-Bomb warning:
Spoiler alert—Berenson is giving you the bottom line.
Here’s that story—I actually read KD on this one this morning:
The trainwreck of all trainwrecks: Billions of people stuck with a broken immune response
Here’s KD’s shorter explanation: Aw, Crap …
Here’s what a new study found out. Multiple mRNA injections bring the IgG3 response down to near zero—and IgG3 anti-bodies account for for over 40% of our immune system’s neutralizing capacity. But IgG4 response—which tells the body to tolerate the infection—goes through the roof. That’s it in a nutshell. The people who made this discovery say it’s just “interesting” but nothing to worry about:
Rintrah’s piece is actually very long. I’m gonna paste in a bunch of it, omitting most of the graphs. And admitting up front that I don’t know whether billions are doomed. But this doesn’t sound like a positive development:
I’ll try to avoid repeating what we already addressed in the previous two articles on this subject. After mRNA vaccination the immune response against Spike is shifting to IgG4, which is how your body responds after repeat exposure to stuff it needs to tolerate, like bee venom, pollen or peanut proteins.
First the big chart, of what you want to see after a SARS-COV-2 infection:
Left you see who does the neutralization [IgG3], right you see what percentage of total antibodies they are. Despite being just 3% of your antibody mass, IgG3 is carrying out 42.2% of the neutralization.
…
If it wasn’t obvious yet, for whatever reason our bodies do seem to be tolerating the spread of this virus through our population. …
Levels of this virus in sewage are back to record heights. Clearly the population isn’t learning to force this virus into the background.
The death toll is rising in unison with the viral load, because the excess mortality is not a direct product of the vaccine, it is an indirect product of the vaccine interfering with our response to this virus:
We have a big wave of deaths in march 2020, then we had two deadly winters, so excess mortality is now supposed to be negative. We already “ran out” of the people who would die during the flu season. Yet 27% more people died than you would expect last week. That’s supposed to worry people with an IQ above room temperature, but they just call it “unexplained” and try to ignore it.
I point this out to you, because I’ve been arguing on Twitter with one of the authors of the study we’re going to look at, who insists that his findings, which fit the other teams whose findings I reported on in the past two posts are “unexpected”, but “nothing to worry about”. I honestly somewhat doubt he genuinely believes this. I want to explain here why the findings are worrying, so let’s start by looking at their findings and what is actually new.
You already know the story: After the second shot, IgG4 begins to show up. This gets worse with the breakthrough infections, then it gets worse again with the third shot. Now we have updated findings from breakthrough infections after the third shot. And this will shock you, but it gets worse again:
On average, the four who had a breakthrough infection after their booster are now at 42.45% IgG4. The cohort as a whole is at 19.27%, up from just 0.04%, so the ones who haven’t had a breakthrough infection yet will end up at a similar position: A response that is entirely IgG4 dominated.
The one useful new thing these guys and gals did was to ask the obvious question: Is this normal for other pathogens we’re commonly exposed to? So they looked at another virus, the virus causing misery for a lot of kids right now, RSV. They saw we don’t respond to RSV with an IgG4 response:
Nobody showed this response to RSV and it’s not even really seen after constant tetanus vaccination.
You just don’t want to see an IgG4 response to a respiratory infection. Out of the IgG’s, it’s mainly IgG3 and some IgG1 you want to see. One of the authors claims that it doesn’t matter that they’re switching to IgG4, because the antibodies don’t just matter for triggering phagocytosis (your immune cells eating the virus particles), they also matter for neutralization.
This is nice and well, but you run into two problems:
The virus evolves. It rapidly evolves to avoid the most neutralizing antibodies. Neutralizing potential against XBB and BQ.1 is basically gone.
IgG4 isn’t really meant for neutralization. Out of the IgG’s, IgG3 is the excellent virus neutralizer. What IgG3 does in the case of SARS2, is that they have their tails bind together. This means that out of all the four subclasses, IgG3 is showing 50-fold stronger neutralization than the other three subclasses against SARS2.
And now it’s time to drink, because have a look at what happens to IgG3 after three shots:
There is some IgG3 left in some people after the second shot, but by the time they get the third shot, they’re all universally down to a flat zero.
…
This has never happened before. There are now the known unknowns, like whether the body ends up tolerating persisting infections due to this completely IgG4 dominated response, along with the unknown unknowns, questions we should be asking ourselves that most people haven’t even realized we need to be asking ourselves.
Here’s the big question I run into: So your experiment failed, you created an IgG4 dominant antibody response in soon to be billions of people. The IgG4 antibody response is homogeneous, it’s the same epitopes that everyone is learning now to tolerate.
Are you ready for this one?
What does it mean for other viruses?
That’s the big painful question. …
...
In other words: A homogeneous population-wide shift towards IgG4 for certain antibodies, can end up impacting our relationship to respiratory viruses other than SARS2 as well. You could expect for example, that vaccinated people may become better asymptomatic spreaders of other respiratory viruses, like RSV. We see evidence of cross-reactive antibodies between SARS2 and the human corona viruses. Do you want those to switch from IgG3 to IgG4? Probably not.
Admittedly we’re now in the realm of both known and unknown unknowns. But it is worrying. Rintrah admits that he’s a college dropout challenging a virologist with a PhD who’s saying: Don’t worry. But he’s still worried:
He is a virologist and things are not going well in the field of viruses. We have too many people dying. We have a sarbecovirus that is not going away. The hospitals around the Western world can’t deal with the burden of sick people anymore.
And most important of all: The children are getting sick.
Maybe you don’t want to endow billions of people with a similar looking IgG4 antibody repertoire targeted at an RNA respiratory virus. Maybe all sorts of respiratory viruses and other pathogens can use that as an opportunity.
You committed an unprecedented experiment with billions of people, our immune systems are now responding in an unprecedented manner to a respiratory pathogen and we now see unprecedented numbers of people sick from respiratory infections.
If you are a virologist, I think you’re supposed to be worried right now.
Update 1: A critique you might have of my warning, that a shift towards IgG4 may impact other respiratory pathogens too, is that cross-reactivity of antibodies may not be sufficient.
And yet, we already know there must be substantial cross-reactivity between SARS2 and a number of other RNA respiratory viruses, for a simple reason: Subunit influenza vaccines (ie not live vaccines) showed a clear 89% reduction in risk of a severe SARS-COV-2 infection.
If influenza antibodies impact SARS2, SARS2 antibodies impact influenza. And if SARS2 antibodies are shifting towards tolerance, that will impact influenza. The impact will merely get more relevant over time, as these other viruses adjust through mutation and natural selection to benefit optimally from this shift towards IgG4.
The problem, of course, is that we don’t really have any reason to trust scientists any more—not without verification.
Earlier today an old Twitter comment (from Twitter Covid revelations quotations) spoke of the horrendous nature of 'anti-vaxxers' (etc., it wasn't the subject but tagged along with the point being made). Useless masks and apparently life changing (for the worse) 'vaccines' were "IN" for the wanna-be righteous Karens of this country. Illnesses from retention of bugs within the useless masks and now "unknown-unknowns" coupled with "Uh, don't worry about those known-unknowns" seem that the tables should be now turned; apparently triple/quad vaxxed covid experiments (people) are much more likely to be asymptomatic Heavy Viral-Load spreaders. This is not to mention, kids who would have had little or no issues with getting covid, got vaxxed and are subject to severe impact of - not only covid - but typical, light-effecting influenza and other RSVs. Maybe for the remainder of their lifetimes (an unknown-unknown).
Perhaps the tables now need to be turned to protect humanity, or at least on a basic, common sense level, the remaining, normal Immune System possessing public?
I resented all the terrible treatment the Karens, Gov't and 'scientists' levied. I will not stoop to their level and 'turn the tables'. However, I am for such multi-vaxxed folks to be 'marked' (maybe made to wear masks?) so I can avoid them somewhat, at my discretion. Hmmm, I guess I am willing to stoop down, some...
Struggle Jennings and Caitlynne Curtis did a song "God we need You now". Seems pretty apropos just now.
This article was very technical and parts of it were hard to understand. However, the fear was always that not only would the vax reduce the effectiveness of the body's immune system that relates directly to fighting Covid, but also that it would impact the body's overall immune system. Most people who are terrified of viruses and bacteria don't realise that our bodies are already full of both. It is the secondary immune system such as killer T-cells that keep all this crap under control. If the shots - and it is still if - are undermining these, then things will get tough for millions of people.